Conversion of histidine to hercynine by Neurospora crassa.
نویسندگان
چکیده
Cell-free extracts of Neurospora crassa mycelium catalyze the methylation of l-histidine to form hercynine (histidine betaine). The partially methylated compounds, alpha-N-methyl-l-histidine and alpha-N,N-dimethyl-l-histidine, are also methylated by the same enzyme preparation to form hercynine. All three methylation reactions are stimulated by the addition of S-adenosylmethionine.
منابع مشابه
The reaction sequence in ergothioneine biosynthesis: hercynine as an intermediate.
Ergothioneine can be synthesized by the mold, Neurospora crassa, from the amino acids, histidine, methionine, and cysteine (1). The intact histidine molecule is used in the synthesis, and the three methyl groups of the betaine moiety can be derived from methionine by a triple transmethylation process (2). Cysteine appears to be an immediate precursor of the sulfur atom of the thiolimidazole rin...
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ورودعنوان ژورنال:
- Journal of bacteriology
دوره 101 3 شماره
صفحات -
تاریخ انتشار 1970